FISH, Prenatal Screen

Test code

14604

CPT code(s)*

88271 (x5), 88274 (x2)

**CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

FISH, Prenatal Screen - This fluorescence in situ hybridization (FISH) prenatal screening test is used for numerical abnormalities of chromosomes X, Y, 13, 18, and 21 in amniotic fluid and chorionic villus samples. Since this is a screening test, the results MUST be evaluated in conjunction with a standard chromosome study or a chromosomal microarray (CMA) study. Medical decisions should not be based solely on FISH screen results. The American College of Medical Genetics recommends that irreversible therapeutic action should not be taken based on the results of FISH analysis alone (Am. J. Hum. Genet. 53: 526-527, 1993).

Test resources

Details

Test details

Methodology

Fluorescence in situ Hybridization (FISH)

Assay category

The analytical performance characteristics of this assay have been determined by Quest Diagnostics. The modifications have not been cleared or approved by the FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Alternative name(s)

Prenatal Screen, FISH,Aneuploidy Screen, AneuVysion™, FISH

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	20 mL amniotic fluid collected in a sterile, screw-cap container
Alternative specimen(s)	30 mg chorionic villi collected in sterile container with Hanks', Ringer's solution or culture medium with antibiotics
Minimum volume	5 mL amniotic fluid • 10 mg chorionic villi
Collection instructions	Clinical history/reason for referral is required with test order.
Transport temperature	Room temperature
Specimen stability	Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not Reject.

Reference range(s)

See Laboratory Report

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
86011003	FISH, Prenatal Screen	57317-0	Chromosome 13+18+21+X+Y aneuploidy

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics Nichols Institute

14225 Newbrook Drive

Chantilly, VA 20153

Setup schedule

Set up: Daily; Report available: 24-48 hours from receipt of sample in laboratory

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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