Chromosome Analysis, Amniotic Fluid

Test code

14590

CPT code(s)*

88235, 88267, 88280

**CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

In-home collection is not available in your area through Quest Mobile.

Clinical significance

Chromosome Analysis, Amniotic Fluid - This test will detect chromosome abnormalities of the fetus including numerical, structural, and mosaic abnormalities. Chromosome analysis will also reveal fetal sex and sex chromosome abnormalities. Indications for prenatal chromosome analysis may include advanced maternal age, abnormal fetal ultrasound, abnormal maternal serum screen, abnormal cell-free DNA results, history of a previous child with a chromosome abnormality, or a parent who carries a balanced chromosomal rearrangement or has another chromosome abnormality.

Test resources

Details

Test details

Methodology

Culture • Karyotype • Microscopy

Alternative name(s)

Karyotype

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	20 mL amniotic fluid collected in a sterile, screw-cap container, or nontoxic centrifuge tubes
Minimum volume	5 mL
Collection instructions	30 mL is preferred if other testing, e.g., microarray, FISH, is ordered. Ship at room temperature. Do not freeze. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab). Note: Patient's age gestational age, and indication(s) for testing are necessary; please submit completed cytogenetics requisition form with information. Do not split even if AFP requested. Send all tubes to lab (supernatant for AFP will be split by cytogenetics lab). Amniotic fluid kit and handling instruction available upon request. Please contact the laboratory Genetic Counselor at 1-866-GENEINFO (1-866-436-3463) with any questions.
Transport temperature	Room temperature
Specimen stability	Specimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.

Reference range(s)

Interpretive report

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
85985060	Chromosome, Amniotic Fluid	33773-3	Karyotype

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup schedule

Set up: Mon-Sat; Report available: 9-12 days

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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