Cortisol, Free, 24-Hour Urine

Cortisol, Free, 24-Hour Urine

Test Code

14534
82530, 82570
14534
82530, 82570
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Cortisol, Free, 24-Hour Urine -

This urinary free cortisol (UFC) test, performed with a 24-hour urine specimen, is one of the preferred tests for screening for and diagnosing Cushing syndrome. This test may also be used to monitor for recurrence of Cushing disease [1]. In addition, when used in conjunction with the measurement of 24-hour urine cortisone, this test may help identify disorders caused by impaired activity of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), such as apparent mineralocorticoid excess (AME) syndrome [2].

UFC level is independent of corticosteroid-binding globulin and albumin levels; ...

Test Resources

Algorithm

Polycystic Ovary Syndrome (PCOS) Diagnostic Algorithm

Clinical Focus

Polycystic Ovary Syndrome (PCOS)

Test Details

Includes

  • Creatinine
  •  
  • CPT code 81050 may be added at an additional charge for volume measurement

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Cortisol, Free, 24-Hr Urine

Adult 4.0-50.0 mcg/24 hrs
Pediatric  
   1-4 Years 0.9-8.2 mcg/24 hrs
   5-9 Years 1.0-30.0 mcg/24 hrs
   10-13 Years 1.0-45.0 mcg/24 hrs
   14-17 Years 3.0-55.0 mcg/24 hrs

Cortisol, Free, Urine
Adult 3.1-42.3 mcg/g creat

Creatinine, 24-Hour Urine
<3 Years Not established
3-8 Years 0.10-0.80 g/24 hours
9-12 Years 0.20-1.40 g/24 hours
13-17 Years 0.40-1.90 g/24 hours
>17 Years 0.50-2.15 g/24 hours

LOINC® Codes, Performing Laboratory

Service Area must be determined
Creatinine

CPT code 81050 may be added at an additional charge for volume measurement

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Cortisol, Free, 24-Hr Urine
Adult 4.0-50.0 mcg/24 hrs
Pediatric  
   1-4 Years 0.9-8.2 mcg/24 hrs
   5-9 Years 1.0-30.0 mcg/24 hrs
   10-13 Years 1.0-45.0 mcg/24 hrs
   14-17 Years 3.0-55.0 mcg/24 hrs

Cortisol, Free, Urine
Adult 3.1-42.3 mcg/g creat

Creatinine, 24-Hour Urine
<3 Years Not established
3-8 Years 0.10-0.80 g/24 hours
9-12 Years 0.20-1.40 g/24 hours
13-17 Years 0.40-1.90 g/24 hours
>17 Years 0.50-2.15 g/24 hours
Service Area must be determined

Preferred Specimen(s)

2 mL urine from a 24-hour collection (no preservatives)

Alternative Specimen(s)

Urine collected with: 10 g boric acid,  10 mL concentrated glacial acetic acid or 25 mL 6N HCl

Minimum Volume

0.5 mL

Collection Instructions

Collect urine with 10 g of boric acid or keep urine refrigerated during collection if preservative is not used. Record 24-hour urine volume on test requisition and urine vial.

Note: Reference ranges do not apply to random urine samples.

Transport Container

Plastic urine container

Transport Temperature

Refrigerated (cold-packs)

Specimen Stability

  • Room temperature: 14 days
  • Refrigerated: 21 days
  • Frozen: 90 days

Setup Schedule

Service Area must be determined
2 mL urine from a 24-hour collection (no preservatives)
Urine collected with: 10 g boric acid,  10 mL concentrated glacial acetic acid or 25 mL 6N HCl
0.5 mL
Collect urine with 10 g of boric acid or keep urine refrigerated during collection if preservative is not used. Record 24-hour urine volume on test requisition and urine vial.

Note: Reference ranges do not apply to random urine samples.
Plastic urine container
Refrigerated (cold-packs)
Room temperature: 14 days
Refrigerated: 21 days
Frozen: 90 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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