ADAMTS13 Activity with Reflex to Inhibitor

Test Code

14532

CPT Code(s)

85397

Test Code

14532

CPT Code(s)

85397

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

ADAMTS13 Activity with Reflex to Inhibitor - ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a life-threatening hematological condition characterized by a low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ...

Test Resources

Test FAQ

ADAMTS13 Activity with Reflex to ADAMTS13 Inhibitor

Test Details

Includes

If the ADAMTS13 Activity result is ≤0.30 IU/mL, then ADAMTS13 Inhibitor will be performed at an additional charge (CPT: 85335).

Methodology

Immunoassay (IA)

Reference Range(s)

ADAMTS13 Activity	0.68-1.63 IU/mL
ADAMTS13 Inhibitor	<0.4 BEU

Alternative Name(s)

vWF-CP,vonWillebrand Factor,vWF Protease Activity,VWF Cleaving Protease

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

If the ADAMTS13 Activity result is ≤0.30 IU/mL, then ADAMTS13 Inhibitor will be performed at an additional charge (CPT: 85335).

Methodology

Immunoassay (IA)

Reference Range(s)

ADAMTS13 Activity	0.68-1.63 IU/mL
ADAMTS13 Inhibitor	<0.4 BEU

Alternative Name(s)

vWF-CP,vonWillebrand Factor,vWF Protease Activity,VWF Cleaving Protease

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Please submit a separate, frozen vial for each special coagulation assay ordered. Draw blood in a light blue-top tube containing 3.2% sodium citrate, mix gently by inverting 3-4 times. Centrifuge 15 minutes at 1500 g within one hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Freeze immediately and transport on dry ice.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1 mL frozen plasma collected in a 3.2% sodium citrate (light blue-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: Unacceptable
Frozen: 21 days

Reject Criteria

Gross hemolysis • Grossly lipemic • Grossly icteric

Setup Schedule

Service Area must be determined

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.