Pharmacogenomics Panel with Coriell Life Sciences (CLS) Report

Pharmacogenomics Panel with Coriell Life Sciences (CLS) Report

Test Code

14271
81418
14271
81418
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Pharmacogenomics Panel with Coriell Life Sciences (CLS) Report - Genetics can play a significant role in the selection of certain medications. For instance, individuals may metabolize medications too fast or too slow. This test analyzes genes of known pharmacogenomic value allowing clinicians to gain valuable insight into an individual's response to and adverse effects from medications with known gene-drug interactions. In partnership with Coriell Life Sciences, this test offers an enhanced report providing medication guidance and clinical annotation based on the genetic results provided by Quest Diagnostics.

Test Resources

Test FAQ

Pharmacogenomics Panel

Test Details

Includes

  • ABCG2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, F5, HLA-A*31:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01, IFNL3, NAT2, NUDT15, SLCO1B1, TPMT, UGT1A1, VKORC1

Patient Preparation

Saliva: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT remove the plastic film from the funnel lid.
Buccal: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT touch swab or allow contact with any other object.

Methodology

Microarray

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

CYP450,DPYD,CYP2D6,Drug metabolism,Polypharmacy,SSRI,UGT1A1,CYP2C9,ABCG2,PGx,Antidepressants,CYP2B6,Cytochrome P450,CYP,CYP2C19,Pharmacogenetics,NAT2,NUDT15,Statin myopathy,Psychiatry,SLCO1B1,Thiopurine toxicity

LOINC® Codes, Performing Laboratory

Service Area must be determined
ABCG2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, CYP4F2, DPYD, F5, HLA-A*31:01, HLA-B*15:02, HLA-B*57:01, HLA-B*58:01, IFNL3, NAT2, NUDT15, SLCO1B1, TPMT, UGT1A1, VKORC1
Saliva: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT remove the plastic film from the funnel lid.
Buccal: Do NOT eat, drink, smoke or chew gum for 30 minutes before collection. Do NOT touch swab or allow contact with any other object.

Methodology

Microarray
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

See Laboratory Report

Alternative Name(s)

CYP450,DPYD,CYP2D6,Drug metabolism,Polypharmacy,SSRI,UGT1A1,CYP2C9,ABCG2,PGx,Antidepressants,CYP2B6,Cytochrome P450,CYP,CYP2C19,Pharmacogenetics,NAT2,NUDT15,Statin myopathy,Psychiatry,SLCO1B1,Thiopurine toxicity
Service Area must be determined

Preferred Specimen(s)

5 mL whole blood collected in an EDTA (lavender-top) tube

Alternative Specimen(s)

Whole blood collected in: ACD (yellow-top) tube • 4 mL saliva collected in an OGD-500 OR OGD-600 Oragene-Dx collection kit up to the "FILL TO" line on the device • 1 buccal swab collected in an OCD100A, ORAcollect-Dx DNA collection kit

Minimum Volume

2 mL whole blood • 3 mL salvia • 1 swab

Transport Container

EDTA (lavender-top) tube

Transport Temperature

Room temperature

Specimen Stability

  • Whole blood
    Room temperature: 30 days
    Refrigerated: 8 days
    Frozen: Unacceptable

    Saliva/buccal swab
    Room temperature: 30 days
    Refrigerated: 30 days
    Frozen: 30 days

Reject Criteria

Gross hemolysis

Setup Schedule

Service Area must be determined
5 mL whole blood collected in an EDTA (lavender-top) tube
Whole blood collected in: ACD (yellow-top) tube • 4 mL saliva collected in an OGD-500 OR OGD-600 Oragene-Dx collection kit up to the "FILL TO" line on the device • 1 buccal swab collected in an OCD100A, ORAcollect-Dx DNA collection kit
2 mL whole blood • 3 mL salvia • 1 swab
EDTA (lavender-top) tube
Room temperature
Whole blood
Room temperature: 30 days
Refrigerated: 8 days
Frozen: Unacceptable

Saliva/buccal swab
Room temperature: 30 days
Refrigerated: 30 days
Frozen: 30 days
Gross hemolysis
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.

Customize the test information for your Service Area