AD-Detect™ ABeta 42/40 and p-tau217 Evaluation, Plasma
Test code
CPT code(s)*
Clinical significance
Test resources
Test FAQ
Details
The information below details the components of this test. For overall setup schedule, see Performing lab & setup schedule.
Included components
Test code | Test name | Orderable separately | Setup schedule |
|---|---|---|---|
| %14260 | AD DETECT BETA AMYLOID42/40 RATIO, PLASMA | No | Not provided |
| %14262 | AD DETECT LIKELIHOODSCORE | No | Not provided |
| %14259 | AD DETECT LIKELIHOODSCORE INTERPRETATION | No | Not provided |
| %14261 | AD DETECT PHOSPHORYLATEDTAU217, PLASMA | No | Not provided |
Includes
AD-Detect Likelihood Score Interpretation
AD-Detect Beta-Amyloid 42/40 Ratio, Plasma
AD-Detect Phosphorylated tau217, Plasma
AD-Detect Likelihood Score
Methodology
Immunoassay (IA) • Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Assay category
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Alternative name(s)
Phosphorylated tau,ptau 217,AB 42,Dementia,Alzheimer's Diagnostic panel,Alzheimer’s Disease,Alzheimer's diagnosis,Amyloid beta 42,Phospho tau
Specimen requirements | |
|---|---|
| Patient preparation | Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample |
| Preferred specimen(s) | 2.5 mL total plasma collected in a K2 EDTA (lavender-top) tube split into two equal aliquots |
| Minimum volume | 1.2 mL |
| Collection instructions | Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended. Collect blood into a K2 EDTA (lavender-top) tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into 2 separate polypropylene tubes or 2 separate Quest issued polypropylene pour-off/transfer tubes. Do not transfer to conical tubes. Store frozen. |
| Transport container | Transport tube(s) |
| Transport temperature | Frozen |
| Specimen stability | Room temperature: Unacceptable Refrigerated: 72 hours Frozen: 28 days |
| Reject criteria | Moderate or gross hemolysis • Specimen collected in a glass, polystyrene, or polycarbonate tube • K3 EDTA tube • K2 EDTA gel separator tube |
Reference Range(s)
| ABeta 42 | Not Established |
| ABeta 40 | Not Established |
| ABeta 42/40 Ratio | ≥0.170 |
| AD Detect p-tau217 | ≤0.15 pg/mL |
| AD Detect Likelihood Score | |
| Likelihood of amyloid PET positivity | |
| Low Likelihood | <0.3254 |
| Indeterminate | 0.3254-0.6460 |
| High Likelihood | >0.6460 |
The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.
NOTE: The codes listed in the table are not orderable Test Codes
Result code | Result name | LOINC code | Component name |
|---|---|---|---|
| 86039418 | INTERPRETATION | Pending assignment | |
| 86039419 | LIKELIHOOD SCORE | Pending assignment | |
| 86039422 | ABETA 42 | 33200-7 | Amyloid beta 42 peptide |
| 86039423 | ABETA 40 | 70073-2 | Amyloid beta 40 peptide |
| 86039424 | ABETA 42/40 RATIO | 106941-8 | Amyloid beta 42 peptide/Amyloid beta 40 peptide |
| 86039425 | AD DETECT PTAU217, PLASMA | 104663-0 | Tau protein.phosphorylated 217 |
Performing laboratory
| Quest Diagnostics Nichols Institute-San Juan Capistrano, CA |
| 33608 Ortega Highway |
| San Juan Capistrano, CA 92675-2042 |
Setup schedule
Information not provided in Great Lakes (IL, WI, IA, MI…) –Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.
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