Neurofilament Light Chain (NfL)

Neurofilament Light Chain (NfL)

Test Code

13979
83884
13979
83884
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Neurofilament Light Chain (NfL) - Neurofilament light (NfL) is an intermediate filament protein found specifically in the neuronal cytoskeleton. It can be released into the extracellular space through axonal degradation, and it has been shown that varying NfL levels are an indicator of neuroaxonal damage, irrespective of the cause, and can therefore be associated with a variety of neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, or Alzheimer's disease, as well as acute situations such as traumatic brain injury and others. NfL is thus considered a promising biomarker for, ...

Test Resources

Test FAQ

Quest Dementia Testing

Clinical Focus

Dementia: Biomarkers for Differential Diagnosis and Alzheimer's Disease Assessment

Test Summary

Neurofilament Light Chain (NfL), Plasma

Test Details

Patient Preparation

Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Methodology

Immunoassay (IA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

<20 yearsNot established
20-29 years<1.17 pg/mL
30-39 years<1.29 pg/mL
40-49 years<2.34 pg/mL
50-59 years<2.21 pg/mL
60-69 years<3.86 pg/mL
70-79 years<5.27 pg/mL
≥80 years<7.05 pg/mL

Alternative Name(s)

Multiple Sclerosis,Alzheimer,Dementia,Neurodegeneration,MS

LOINC® Codes, Performing Laboratory

Service Area must be determined
Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Methodology

Immunoassay (IA)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

<20 yearsNot established
20-29 years<1.17 pg/mL
30-39 years<1.29 pg/mL
40-49 years<2.34 pg/mL
50-59 years<2.21 pg/mL
60-69 years<3.86 pg/mL
70-79 years<5.27 pg/mL
≥80 years<7.05 pg/mL

Alternative Name(s)

Multiple Sclerosis,Alzheimer,Dementia,Neurodegeneration,MS
Service Area must be determined

Preferred Specimen(s)

0.7 mL plasma collected in an EDTA (lavender-top) tube

Alternative Specimen(s)

Serum

Minimum Volume

0.5 mL

Collection Instructions

Draw blood in an EDTA (lavender-top) tube. Invert to mix with preservatives. Centrifuge and transfer plasma to a labeled plastic transport tube.

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 21 days
    Refrigerated: 21 days
    Frozen: 36 days

Setup Schedule

Service Area must be determined
0.7 mL plasma collected in an EDTA (lavender-top) tube
Serum
0.5 mL
Draw blood in an EDTA (lavender-top) tube. Invert to mix with preservatives. Centrifuge and transfer plasma to a labeled plastic transport tube.
Transport tube
Room temperature
Room temperature: 21 days
Refrigerated: 21 days
Frozen: 36 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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