Quest AD-Detect® Phosphorylated tau217(p-tau217), Plasma

Test Code

13825

CPT Code(s)

84393

Test Code

13825

CPT Code(s)

84393

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Quest AD-Detect® Phosphorylated tau217(p-tau217), Plasma - Current research indicates that plasma p-tau, including p-tau 217, is concordant with amyloid status defined by either CSF biomarker testing or PET scan analysis, and is able to differentiate between AD and non-AD neurodegenerative diseases and to predict progression to AD. Blood-based biomarkers, such as plasma p-tau, could potentially be used as inclusion criteria or to evaluate target engagement and treatment efficacy, and could further advance the development of disease-modifying treatments in the field of AD and related disorders. This assay is designed specifically for the quantitative measurement of tau phosphorylated at threonine 217 (p-tau 217) in human plasma.

Test Resources

Test FAQ

Quest Dementia Testing

Clinical Focus

Dementia: Biomarkers for Differential Diagnosis and Alzheimer's Disease Assessment

Test Details

Patient Preparation

Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Methodology

Immunoassay (IA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

≤0.15 pg/mL

Alternative Name(s)

pT217,Phosphorylated Tau 217 (217P),Tau protein,Alzheimer,Ptau217,Phosphorylated tau217,plasma pTau species 217,Dementia

LOINC® Codes, Performing Laboratory

Service Area must be determined

Patient Preparation

Patients should be cautioned to stop biotin consumption at least 72 hours prior to collection of a sample

Methodology

Immunoassay (IA)

Assay Category

Reference Range(s)

≤0.15 pg/mL

Alternative Name(s)

pT217,Phosphorylated Tau 217 (217P),Tau protein,Alzheimer,Ptau217,Phosphorylated tau217,plasma pTau species 217,Dementia

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

0.7 mL plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Follow standard protocol for specimen collection and centrifugation then transfer plasma to a labeled plastic transport tube.

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 28 days

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

0.7 mL plasma collected in an EDTA (lavender-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Follow standard protocol for specimen collection and centrifugation then transfer plasma to a labeled plastic transport tube.

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

Room temperature: 5 days
Refrigerated: 14 days
Frozen: 28 days

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection may be available in your area for purchase through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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