Plasma Renin Activity with Reflex to Aldosterone
Test Code
13817
84244
Clinical Significance
Plasma Renin Activity with Reflex to Aldosterone - A suppressed Plasma Renin Activity (PRA), ≤1 ng/mL/hr, will reflex to Aldosterone test. This test is to screen patients for Primary Aldosteronism (PA). PA is under-recognized and the most common cause of secondary hypertension. Patients with untreated PA are at a higher risk of cardiovascular, kidney and metabolic disease when compared to essential hypertensive patients.
Test Details
If Plasma Renin Activity result is ≤1.00 ng/mL/h, then Aldosterone will be performed at an additional charge (CPT code(s): 82088).
Methodology
Chromatography/Mass Spectrometry
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
Reference Range(s)
See Laboratory Report
Preferred Specimen(s)
1.8 mL frozen plasma collected in an EDTA (lavender-top) tube
Minimum Volume
0.8 mL
Collection Instructions
Collection is not limited to mid-morning; patient needs to sit at least 5 minutes prior to collection
Transport Container
Transport tube
Transport Temperature
Frozen
Specimen Stability
- Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days
Reject Criteria
Moderate to gross hemolysis • Received thawed • Plasma collected in a plasma separator tube (PST)
Setup Schedule
1.8 mL frozen plasma collected in an EDTA (lavender-top) tube
0.8 mL
Collection is not limited to mid-morning; patient needs to sit at least 5 minutes prior to collection
Transport tube
Frozen
Room temperature: 24 hours
Refrigerated: 24 hours
Frozen: 28 days
Refrigerated: 24 hours
Frozen: 28 days
Moderate to gross hemolysis • Received thawed • Plasma collected in a plasma separator tube (PST)