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FISH, AML Targeted Panel

Test code

13730

CPT code(s)*

88271 (x12), 88275 (x6)
Notices
**CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide Service Area Information to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical significance

FISH, AML Targeted Panel - The Acute Myeloid Leukemia (AML) targeted FISH panel provide rapid detection of key WHO defining cytogenetic abnormalities that confirm diagnosis and disease classification, guide immediate and long-term therapy, and contribute to prognostication in patients with or suspected of having AML. The panel complements conventional cytogenetics and molecular testing and covers the following genomic alterations: t(8;21)(RUNX1::RUNX1T1), inv(16)/ t(16;16)(CBFB::MYH11), t(15;17)(PML::RARA), t(9;22)(BCR:: ABL1),11q23(KMT2A) rearrangements, and 17p13 (TP53) deletion. The results of this assay help distinguish AML subtypes (e.g., Acute…
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Test resources

Test summary

Acute Myeloid Leukemia (AML), Rapid Mutation Panel

Details

Test details

Includes

If results are not possible from the submitted specimen, the test order will be cancelled and replaced by non-orderable test Cytogenetics Communication.

Note: STAT handling for PML-RARA component is available only by request. Please include a note STAT for PML-RARA, MD contact name, and phone number to receive preliminary STAT results.

Methodology

Fluorescence in situ Hybridization (FISH)

Assay category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Alternative name(s)

Acute Myeloid Leukemia,BCR-ABL1,Inv(16),t(16;16),RUNX1/RUNX1T1,AML1/ETO,t(8;21),KMT2A,TP53 deletion,P53 deletion,MLL,17p,t(9;22),CBFB,CBFB-MYH11,t(15;17)

Specimen requirements
Patient preparationNone Specified
Preferred specimen(s)5 mL whole blood or 3 mL bone marrow collected in a sodium heparin (green-top) tube
Alternative specimen(s)EDTA (lavender-top) tube
Minimum volume3 mL whole blood • 1 mL bone marrow
Collection instructionsClinical history and reason for referral are required with test order. Prior therapy and bone marrow transplant history should be provided with test order.
Transport containerSodium heparin (green-top) tube
Transport temperatureRoom temperature
Specimen stabilitySpecimen viability decreases during transit. Send specimen to testing lab for viability determination. Do not freeze. Do not reject.
Reject criteriaReceived frozen
Service Area Information
Service Area Information

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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