PrEP RPR (Diagnosis) with Reflex Titer and Treponema pallidum Antibody, IA

Test code

13698

CPT code(s)*

86592

**CPT Code is subject to a Medicare Limited Coverage Policy and may require a signed ABN when ordering.

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Clinical significance

PrEP RPR (Diagnosis) with Reflex Titer and Treponema pallidum Antibody, IA - RPR is a nontreponemal (lipoidal antigen) test used to screen for syphilis. Positive RPR samples are reflexed to determine titer and to a confirmatory treponemal assay as part of the traditional algorithm. False positive results associated with various medical conditions, including other infections (e.g., HIV), autoimmune conditions, vaccinations, injecting drug use, pregnancy, and older age may occur with the RPR test.This assay may be performed as part of an overall screening regimen for patients considering or who are currently taking HIV PrEP. Please refer to the "Preexposure Prophylaxis for the…

Test resources

Test FAQ

HIV Pre-exposure Prophylaxis (PrEP) Testing

Test guide

HIV Pre-Exposure Prophylaxis (PrEP): Laboratory Testing

Details

Test details

Includes

If RPR screen is Reactive, then RPR Titer and Treponema pallidum Antibody, IA for Confirmatory testing will be performed at an additional charge (CPT Code(s): 86593, 86780).

Methodology

Flocculation

Alternative name(s)

PrEP Syphilis Serology Screen,PrEP Rapid Plasma Reagin,PrEP RPR(DX) rfl Ttr/T.pallidum

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	3 mL serum
Minimum volume	1 mL
Transport container	Transport tube
Transport temperature	Room temperature
Specimen stability	Room temperature: 4 days Refrigerated: 7 days Frozen: 30 days
Reject criteria	Hemolysis • Lipemia

Reflex tests

Test code	Test name	Orderable separately	Reflex criteria
%13699	PrEP RPR TITER	No	If RPR screen is Reactive, then RPR Titer will be performed.
%13700	PrEP TREPONEMA PALLIDUM AB	No	If RPR screen is Reactive, then Treponema pallidum Antibody, IA for Confirmatory testing will be performed.

Reference range(s)

Reference Range(s)

PrEP RPR(DX) w/Rfl Titer and Confirm Test	Non-Reactive
PrEP RPR Titer	Not applicable
PrEP Treponema pallidum Ab	Negative

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
86038458	PrEP RPR (DX) W/RFL TITER AND CONFIRMATORY TEST	20507-0	Reagin Ab

PrEP RPR TITER

Result code	Result name	LOINC code	Component name
86038459	PrEP RPR TITER	31147-2	Reagin Ab

PrEP TREPONEMA PALLIDUM AB

Result code	Result name	LOINC code	Component name
86038460	PrEP TREPONEMA PALLIDUM AB	24110-9	Treponema pallidum Ab

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics - East Region

Setup schedule

Information not provided in East (Eastern PA, MD, DE, VA, NY, NJ, Southern CT) – Contact lab or Customer service to determine turnaround time

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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