Quest AD-Detect® Phosphorylated tau181(p-tau181), Plasma

Quest AD-Detect® Phosphorylated tau181(p-tau181), Plasma

Test Code

13690
84393
13690
84393
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Quest AD-Detect® Phosphorylated tau181(p-tau181), Plasma - p-tau181 is a diagnostic biomarker for Alzheimer's Disease (AD) that is useful in identifying patients with underlying AD tau pathology. It can predict the cognitive decline in AD/MCI patients and correlates with amyloid and tau PET results.

Test Resources

Test FAQ

Quest Dementia Testing

Clinical Focus

Dementia: Biomarkers for Differential Diagnosis and Alzheimer's Disease Assessment

Test Details

Patient Preparation

Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Methodology

Electrochemiluminescence (ECLIA)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

<55 years≤0.86 pg/mL
≥55 years≤1.07 pg/mL

Alternative Name(s)

PhosphoTau-181P

LOINC® Codes, Performing Laboratory

Service Area must be determined
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Methodology

Electrochemiluminescence (ECLIA)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

<55 years≤0.86 pg/mL
≥55 years≤1.07 pg/mL

Alternative Name(s)

PhosphoTau-181P
Service Area must be determined

Preferred Specimen(s)

1 mL plasma collected in EDTA (lavender-top) tube

Minimum Volume

0.5 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 14 days
    Refrigerated: 22 days
    Frozen: 22 days

Reject Criteria

Hemolysis

Setup Schedule

Service Area must be determined
1 mL plasma collected in EDTA (lavender-top) tube
0.5 mL
Transport tube
Room temperature
Room temperature: 14 days
Refrigerated: 22 days
Frozen: 22 days
Hemolysis
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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