Diabetes Type 1 Autoantibody Panel

Test code

13621

CPT code(s)*

86337, 86341 (x3)

In-home collection may be available in your area for purchase through Quest Mobile.

Clinical significance

Diabetes Type 1 Autoantibody Panel - The American Diabetes Association supports using autoantibody (AAb) screening to diagnose T1D. T1D autoantibodies are markers of ongoing damage to insulin-producing beta cells. The four AAbs used in clinical practice to diagnose T1D are: AAbs against insulin (IAA), tyrosine phosphatase IA2 (IA2A), glutamic acid decarboxylase (GAD65), and zinc transporter. Numerous clinical trials demonstrate important clinical benefits associated with detecting T1D using an AAb screening approach.Clinical guidelines have been established to help identify T1D at its earliest phases and before progression to DKA, providing presymptomatic and symptomatic…

Test resources

Details

Test details

The information below details the components of this test. For overall setup schedule, see Performing lab & setup schedule.

Included components

Test code	Test name	Orderable separately	Setup schedule
%34878	GLUTAMIC ACIDDECARBOXYLASE 65 AB	No	Not provided
37933	IA-2 Antibody	Yes	Set up: Tues, Thurs, Sat; Report available: 7 days
36178	Insulin Autoantibody	Yes	Set up: Sun, Tues, Thurs; Report available: 7 days
%13946	ZINC TRANSPORTER 8 (ZnT8)ANTIBODY	No	Not provided

Includes

Glutamic Acid Decarboxylase 65 Ab
Insulin Autoantibody
IA-2 Antibody
Zinc Transporter 8 (ZnT8) Antibody

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA) • Radiobinding Assay (RBA)

Alternative name(s)

Insulin autoantibody (IAA),Tyrosine phosphatase (IA2),Zinc transporter 8 (ZnT8),Glutamic acid decarboxylase (GAD65)

Specimen requirements
Patient preparation	None Specified
Preferred specimen(s)	4 mL serum
Minimum volume	2 mL
Transport container	Transport tube
Transport temperature	Room temperature
Specimen stability	Room temperature: 7 days Refrigerated: 7 days Frozen 28 days
Reject criteria	Gross hemolysis • Lipemia • Icterus • Specimens other than serum

Reference range(s)

Reference Range(s)

Glutamic Acid Decarboxylase 65 Ab	<5 IU/mL
Insulin Autoantibody	<0.4 U/mL
IA-2 Antibody	<5.4 U/mL
Zinc Transporter 8 (ZnT8) Antibody	<15 U/mL

LOINC® codes

The Result and LOINC® information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table are not orderable Test Codes

Result code	Result name	LOINC code	Component name
85987230	INSULIN AUTOANTIBODY	5232-4	Insulin Ab
86015478	GLUTAMIC ACID DECARBOXYLASE 65 AB	56540-8	Glutamate decarboxylase 65 Ab
86024792	IA-2 ANTIBODY	56718-0	Islet cell 512 Ab
86038899	ZINC TRANSPORTER 8 (ZnT8) ANTIBODY	76651-9	Zinc transporter 8 Ab

Performing lab & setup schedule

Performing laboratory

Quest Diagnostics Nichols Institute-San Juan Capistrano, CA

33608 Ortega Highway

San Juan Capistrano, CA 92675-2042

Setup schedule

Information not provided in East (Eastern PA, MD, DE, VA, NY, NJ, Southern CT) – Contact lab or Customer service to determine turnaround time

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

*The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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