Diabetes Type 1 Autoantibody Panel

Diabetes Type 1 Autoantibody Panel

Test Code

13621
86337, 86341 (x3)
13621
86337, 86341 (x3)
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Diabetes Type 1 Autoantibody Panel - The American Diabetes Association supports using autoantibody (AAb) screening to diagnose T1D. T1D autoantibodies are markers of ongoing damage to insulin-producing beta cells. The four AAbs used in clinical practice to diagnose T1D are: AAbs against insulin (IAA), tyrosine phosphatase IA2 (IA2A), glutamic acid decarboxylase (GAD65), and zinc transporter. Numerous clinical trials demonstrate important clinical benefits associated with detecting T1D using an AAb screening approach.

Clinical guidelines have been established to help identify T1D at its earliest phases and before progression to DKA, providing presymptomatic and symptomatic staging of T1D.

Test Resources

Test FAQ

Autoantibodies and Type 1 Diabetes (T1D)

Algorithm

Staging presymptomatic patients using Diabetes Type 1 Autoantibody Panel

Test Guide

Laboratory Testing for Diabetes Diagnosis, Risk Assessment, and Management

Test Summary

Diabetes Type 1 Autoantibody Panel

Test Details

Includes

  • Glutamic Acid Decarboxylase 65 Ab
    Insulin Autoantibody
    IA-2 Antibody
    Zinc Transporter 8 (ZnT8) Antibody

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA) • Radiobinding Assay (RBA)

Reference Range(s)

Glutamic Acid Decarboxylase 65 Ab<5 IU/mL
Insulin Autoantibody<0.4 U/mL
IA-2 Antibody<5.4 U/mL
Zinc Transporter 8 (ZnT8) Antibody<15 U/mL

Alternative Name(s)

Insulin autoantibody (IAA),Tyrosine phosphatase (IA2),Zinc transporter 8 (ZnT8),Glutamic acid decarboxylase (GAD65)

LOINC® Codes, Performing Laboratory

Service Area must be determined
Glutamic Acid Decarboxylase 65 Ab
Insulin Autoantibody
IA-2 Antibody
Zinc Transporter 8 (ZnT8) Antibody

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA) • Radiobinding Assay (RBA)

Reference Range(s)

Glutamic Acid Decarboxylase 65 Ab<5 IU/mL
Insulin Autoantibody<0.4 U/mL
IA-2 Antibody<5.4 U/mL
Zinc Transporter 8 (ZnT8) Antibody<15 U/mL

Alternative Name(s)

Insulin autoantibody (IAA),Tyrosine phosphatase (IA2),Zinc transporter 8 (ZnT8),Glutamic acid decarboxylase (GAD65)
Service Area must be determined

Preferred Specimen(s)

4 mL serum

Minimum Volume

2 mL

Transport Container

Transport tube

Transport Temperature

Room temperature

Specimen Stability

  • Room temperature: 7 days
    Refrigerated: 7 days
    Frozen 28 days

Reject Criteria

Gross hemolysis • Lipemia • Icterus • Specimens other than serum

Setup Schedule

Service Area must be determined
4 mL serum
2 mL
Transport tube
Room temperature
Room temperature: 7 days
Refrigerated: 7 days
Frozen 28 days
Gross hemolysis • Lipemia • Icterus • Specimens other than serum
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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