Quest AD-Detect® Apolipoprotein E (ApoE) Isoform, Plasma

Quest AD-Detect® Apolipoprotein E (ApoE) Isoform, Plasma

Test Code

12563
82542
12563
82542
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Quest AD-Detect® Apolipoprotein E (ApoE) Isoform, Plasma - Apolipoprotein E (ApoE) is a well-defined genetic risk factor for late-onset Alzheimer's disease (AD). The human APOE gene has three polymorphic alleles, E2, E3 and E4 that result in six different genotypes: E2/E2, E2/E3, E3/E3, E2/ E4, E3/E4 and E4/E4. About half of AD patients carry the E4 allele (compared with 14% in the general population), with the majority being heterozygotes (E3/E4). The number of inherited E4 alleles is associated with both increased disease risk and decreased average age of onset compared with inheritance of the E2 or E3 alleles. The differences between the three ApoE ...

Test Resources

Test FAQ

Quest Dementia Testing

Clinical Focus

Dementia: Biomarkers for Differential Diagnosis and Alzheimer's Disease Assessment

Test Details

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Not established

Alternative Name(s)

Amyloid imaging abnormalities,Alzheimer's Disease (AD),ApoE2,ApoE3,ApoE4,ARIA,Amyloid immunotherapy,Anti-amyloid immunotherapy

LOINC® Codes, Performing Laboratory

Service Area must be determined

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Not established

Alternative Name(s)

Amyloid imaging abnormalities,Alzheimer's Disease (AD),ApoE2,ApoE3,ApoE4,ARIA,Amyloid immunotherapy,Anti-amyloid immunotherapy
Service Area must be determined

Preferred Specimen(s)

1 mL plasma collected in a K2 EDTA (lavender-top) tube

Minimum Volume

0.5 mL

Collection Instructions

Collect blood into a K2 EDTA Plasma tube and mix by inversion 10 times. Centrifuge specimen to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a polypropylene tube or one of the Quest issued polypropylene pour-off/ transfer tubes. Do not transfer to conical tube. If unable to centrifuge within 1 hour of collection, store tube on ice. Store frozen.

Note: Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended.

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 72 hours
    Refrigerated: 14 days
    Frozen: 32 days

Setup Schedule, Transport Container

Service Area must be determined
1 mL plasma collected in a K2 EDTA (lavender-top) tube
0.5 mL
Collect blood into a K2 EDTA Plasma tube and mix by inversion 10 times. Centrifuge specimen to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a polypropylene tube or one of the Quest issued polypropylene pour-off/ transfer tubes. Do not transfer to conical tube. If unable to centrifuge within 1 hour of collection, store tube on ice. Store frozen.

Note: Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended.
Refrigerated (cold packs)
Room temperature: 72 hours
Refrigerated: 14 days
Frozen: 32 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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