Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma

Test Code

11786

CPT Code(s)

82233, 82234

Test Code

11786

CPT Code(s)

82233, 82234

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma - This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.

Test Resources

Test FAQ

Quest Dementia Testing

Clinical Focus

Dementia: Biomarkers for Differential Diagnosis and Alzheimer's Disease Assessment

Test Details

Includes

ABeta 42
ABeta 40
ABeta 42/40 Ratio

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

ABeta 42	Not established	pg/mL
ABeta 40	Not established	pg/mL
ABeta 42/40 Ratio	≥0.170

Alternative Name(s)

ABeta 42,ABeta 40,AB40,AB42,Alzheimer's Disease (AD),AB42/40,AD,ABeta 42/40

LOINC® Codes, Performing Laboratory

Service Area must be determined

Includes

ABeta 42
ABeta 40
ABeta 42/40 Ratio

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

Reference Range(s)

ABeta 42	Not established	pg/mL
ABeta 40	Not established	pg/mL
ABeta 42/40 Ratio	≥0.170

Alternative Name(s)

ABeta 42,ABeta 40,AB40,AB42,Alzheimer's Disease (AD),AB42/40,AD,ABeta 42/40

LOINC® Codes, Performing Laboratory

Service Area must be determined

Preferred Specimen(s)

1.2 mL plasma collected in K2 EDTA tube

Minimum Volume

0.6 mL

Collection Instructions

Collect blood into a K2 EDTA Plasma tube and mix by inversion 10 times. Centrifuge to separate plasma from cells within 1 hour of collection. Carefully transfer plasma into a polypropylene tube or one of the Quest issued polypropylene pour-off/transfer tubes. Do not transfer to conical tube. If unable to centrifuge within 1 hour of collection, store tube on ice. Store frozen.

Note: Quest Diagnostics does not perform this test for individuals under the age of 18. Pre-test and post-test counseling is strongly recommended.

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen -20° C: 32 days
Frozen -70° C: 77 days

Reject Criteria

Moderate or gross hemolysis • Specimen collected in a glass, polystyrene, or polycarbonate tube

Setup Schedule

Service Area must be determined

Preferred Specimen(s)

1.2 mL plasma collected in K2 EDTA tube

Minimum Volume

0.6 mL

Collection Instructions

Transport Container

Transport tube

Transport Temperature

Frozen

Specimen Stability

Room temperature: Unacceptable
Refrigerated: 72 hours
Frozen -20° C: 32 days
Frozen -70° C: 77 days

Reject Criteria

Moderate or gross hemolysis • Specimen collected in a glass, polystyrene, or polycarbonate tube

Setup Schedule

Service Area must be determined

Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to find available tests you can order.

In-home collection is not available in your area through Quest Mobile.

Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

The tests listed by specialty and category are a select group of tests offered. For a complete list of Quest Diagnostics tests, please adjust the filter options chosen, or refer to our Directory of Services.