Lambert-Eaton Syndrome Antibody Panel

Lambert-Eaton Syndrome Antibody Panel

Test Code

11306
86041, 86043, 86596, 86255
11306
86041, 86043, 86596, 86255
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.

Clinical Significance

Lambert-Eaton Syndrome Antibody Panel - Lambert-Eaton myasthenic syndrome is a paraneoplastic phenomena associated with small cell lung cancer. There is a decrease of voltage-gated calcium channels on presynaptic nerve terminals due to an auto-antibody reactive with the channels. There is an associated proximal muscle weakness and often coexisting thyroid autoimmune disease and vitiligo.

Test Resources

Clinical Focus

Paraneoplastic Neurological Syndromes: Laboratory Support of Diagnosis

Test Details

Includes

  • Acetylcholine Receptor Binding Antibody
    Acetylcholine Receptor Modulating Antibody
    Striated Muscle Antibody with Reflex to Titer
    Voltage Gated Calcium Channel Antibody Assay

    If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Methodology

Immunoassay (IA) • Immunofluorescence Assay (IFA) • Radiobinding Assay (RBA)

Assay Category

Acetylcholine Receptor Modulating Antibody: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Alternative Name(s)

LES

LOINC® Codes, Performing Laboratory

Service Area must be determined
Acetylcholine Receptor Binding Antibody
Acetylcholine Receptor Modulating Antibody
Striated Muscle Antibody with Reflex to Titer
Voltage Gated Calcium Channel Antibody Assay

If Striated Muscle Antibody Screen is positive, then Striated Muscle Antibody Titer will be performed at an additional charge (CPT code(s): 86256).

Methodology

Immunoassay (IA) • Immunofluorescence Assay (IFA) • Radiobinding Assay (RBA)
Acetylcholine Receptor Modulating Antibody: This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Alternative Name(s)

LES
Service Area must be determined

Preferred Specimen(s)

2 mL serum

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 48 hours
  • Refrigerated: 7 days
  • Frozen: 30 days

Reject Criteria

Hemolysis • Lipemia • Icteric • Contaminated specimens • Radioactive compounds from in vivo testing • Received room temperature

Setup Schedule

Service Area must be determined
2 mL serum
Transport tube
Refrigerated (cold packs)
Room temperature: 48 hours
Refrigerated: 7 days
Frozen: 30 days
Hemolysis • Lipemia • Icteric • Contaminated specimens • Radioactive compounds from in vivo testing • Received room temperature
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection may be available in your area for purchase through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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