Cortisol, Free, 24-Hour Urine with Creatinine, LC/MS/MS

Cortisol, Free, 24-Hour Urine with Creatinine, LC/MS/MS

Test Code

11280
82530, 82570
11280
82530, 82570
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.

Clinical Significance

Cortisol, Free, 24-Hour Urine with Creatinine, LC/MS/MS - Urinary Free Cortisol is useful in the detection of patients with Cushing's syndrome for whom Free Cortisol concentrations are elevated.

Test Resources

None found for this test
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Test Details

Includes

  • CPT code 81050 may be added at an additional charge for volume measurement

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Assay Category

This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Cortisol, Free, 24-Hr Urine

 Adult 4.0-50.0
 Pediatric  
   1-4 Years 0.9-8.2 mcg/24 hrs
   5-9 Years 1.0-30.0 mcg/24 hrs
   10-13 Years 1.0-45.0 mcg/24 hrs
   14-17 Years 3.0-55.0 mcg/24 hrs

Creatinine, 24-Hour Urine
<3 Years Not established
3-8 Years 0.10-0.80 g/24 hours
9-12 Years 0.20-1.40 g/24 hours
13-17 Years 0.40-1.90 g/24 hours
>17 Years 0.50-2.15 g/24 hours

LOINC® Codes, Performing Laboratory

Service Area must be determined
CPT code 81050 may be added at an additional charge for volume measurement

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.

Reference Range(s)

Cortisol, Free, 24-Hr Urine
 Adult 4.0-50.0
 Pediatric  
   1-4 Years 0.9-8.2 mcg/24 hrs
   5-9 Years 1.0-30.0 mcg/24 hrs
   10-13 Years 1.0-45.0 mcg/24 hrs
   14-17 Years 3.0-55.0 mcg/24 hrs

Creatinine, 24-Hour Urine
<3 Years Not established
3-8 Years 0.10-0.80 g/24 hours
9-12 Years 0.20-1.40 g/24 hours
13-17 Years 0.40-1.90 g/24 hours
>17 Years 0.50-2.15 g/24 hours
Service Area must be determined

Preferred Specimen(s)

2 mL urine from a 24-hour collection (no preservatives)

Alternative Specimen(s)

25 mL 6N HCl • 10 mL concentrated glacial acetic acid • 10 g boric acid

Minimum Volume

0.5 mL

Collection Instructions

Record 24-hour urine volume on test requisition and urine vial. Reference ranges do not apply to random urine samples.

Transport Container

Transport tube

Transport Temperature

Refrigerated (cold packs)

Specimen Stability

  • Room temperature: 14 days
  • Refrigerated: 21 days
  • Frozen: 90 days

Setup Schedule

Service Area must be determined
2 mL urine from a 24-hour collection (no preservatives)
25 mL 6N HCl • 10 mL concentrated glacial acetic acid • 10 g boric acid
0.5 mL
Record 24-hour urine volume on test requisition and urine vial. Reference ranges do not apply to random urine samples.
Transport tube
Refrigerated (cold packs)
Room temperature: 14 days
Refrigerated: 21 days
Frozen: 90 days
Service Area must be determined
Not offered in Quest Diagnostics Nichols Institute (IFD) – San Juan Capistrano. Please provide SERVICE AREA INFORMATION to confirm Test Code for the lab that services your account or to find available tests you can order.
In-home collection is not available in your area through Quest Mobile.
Test Details

Clinical Significance

Test Resources

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidance and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

This material contains content from LOINC® (http://loinc.org). The LOINC Table, LOINC Table Core are copyright © 1995-2019, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee and is available at no cost under the license at http://loinc.org/license.

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