Lupus Panel 4 with ANA, IFA with Reflex to Titer and Pattern
Test Code
Clinical Significance
Lupus Panel 4 with ANA, IFA with Reflex to Titer and Pattern -
This panel can be helpful in the diagnosis of systemic lupus erythematosus (SLE) and several other autoimmune diseases, including mixed connective tissue disease, Sjogren syndrome, systemic sclerosis, and autoimmune thyroid disease. The panel simultaneously tests for antinuclear antibodies (ANAs) with an immunofluorescence assay (IFA), performed on human epithelial type 2 (HEp-2) cells, and 11 biomarkers associated with these conditions. For specimens with positive ANA IFA results, reflex testing for ANA titer and pattern is performed.
The ANA testing has high sensitivity (97%) for SLE ...
Test Resources
Clinical Focus
Autoimmune Rheumatic and Related DiseasesTest Details
Complement Component C3c and C4c
DNA (ds) Antibody
Ribosomal P Antibody
Sm Antibody
Sm/RNP Antibody
Sjogren’s Antibodies (SS-A, SS-B)
Thyroid Peroxidase Antibody (TPO)
Scleroderma Antibody (Scl-70)
Rheumatoid Factor
If the ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).
Methodology
Reference Range(s)
Alternative Name(s)
Preferred Specimen(s)
4 mL serum
Minimum Volume
2 mL
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: Unacceptable
Refrigerated: 7 days
Frozen: 8 days
Reject Criteria
Gross hemolysis • Grossly lipemic • Grossly icteric
Setup Schedule
Refrigerated: 7 days
Frozen: 8 days