Enhanced Liver Fibrosis (ELF) Score
Test Code
Clinical Significance
Enhanced Liver Fibrosis (ELF) Score - The Enhanced Liver Fibrosis (ELF) score predicts progression to cirrhosis and liver-related events in patients with advanced fibrosis due to NASH.
The ELF score is not for use in the diagnosis of NASH, the staging of fibrosis, the serial monitoring of disease progression, or the monitoring of effects of therapeutic products.
The ELF score is derived from an algorithm that combines measurements of PIIINP, TIMP-1, and HA. PIIINP is a marker of early fibrogenesis and inflammation, TIMP-1 is the circulating inhibitor of MMP enzymes that can enhance fibrogenesis, and HA ...
Test Resources
Test FAQ
Enhanced Liver Fibrosis (ELF) ScoreTest Summary
Enhanced Liver Fibrosis (ELF) ScoreTest Details
Methodology
Reference Range(s)
ELF score ranges and associated risk of disease progression (development of cirrhosis or liver-related events):
| <9.80 | Lower |
| ≥9.80 - <11.30 | Mid |
| ≥11.30 | Higher |
Alternative Name(s)
Preferred Specimen(s)
1 mL serum
Minimum Volume
0.5 mL
Collection Instructions
Spin sample within two hours after collection.
Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Samples with fluorescein may cause falsely depressed results. Evidence suggests that patients undergoing retinal fluorescein angiography can retain amounts of fluorescein in the body for up to 72 hours post-treatment.
Transport Container
Transport tube
Transport Temperature
Refrigerated (cold packs)
Specimen Stability
- Room temperature: 48 hours
- Refrigerated: 7 days
- Frozen: 30 days
Reject Criteria
Gross hemolysis
Setup Schedule
Dietary supplements containing biotin may interfere in assays and may skew analyte results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.
Samples with fluorescein may cause falsely depressed results. Evidence suggests that patients undergoing retinal fluorescein angiography can retain amounts of fluorescein in the body for up to 72 hours post-treatment.
Refrigerated: 7 days
Frozen: 30 days