Traditional Algorithm for Serologic Diagnosis of Syphilis

This algorithm provides information about the serologic diagnosis of syphilis using the traditional algorithm.

Test Code 36126

RPR (Diagnosis) with Reflex to Titer and Treponema pallidum Antibody, IA (Traditional)

This test is used to aid in the diagnosis of syphilis using the traditional algorithm. The algorithm starts with RPR, a nontreponemal (lipoidal antigen) serologic test, and if reactive will reflex to titer. Reactive RPR samples will be further tested with the Treponema pallidum Antibody immunoassay, a treponemal serologic test.

Testing can be performed for individuals suspected of syphilis based on signs and symptoms or for screening asymptomatic individuals. Screening is recommended in certain populations at increased risk for infection and pregnant women.

False positive results with nontreponemal (lipoidal antigen) test results may occur due to wide range of biological conditions (e.g. autoimmune disease, cancer, infectious diseases, old age, and pregnancy). False negatives can occur in persons with recent exposure. Persons with previously treated syphilis will remain positive using a treponemal test. Therefore, a single type of serological test is insufficient for diagnosis and positive result using a nontreponemal (lipoidal antigen) test should be confirmed by a treponemal specific assay using the traditional algorithm.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

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